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The treatment policy estimand reflected the intention-to-treat principle by including all study participants randomly assigned to each treatment, using data regardless of discontinuation of study medications and/or use of additional anti-diabetic medications during the trial [28, 29]

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Your home refrigerator's standard setting typically falls within this window, making safe storage straightforward for most patients

During infection, selective removal of damaged mitochondria via PINK1/Parkin-dependent mitophagy limits mtROS accumulation and prevents excessive inflammasome activation (Xu et al., 2024)

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If the liquid inside the pen or vial freezes, the peptide molecules are crushed by the formation of ice crystals